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filingDate 1986-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1992-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1992-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0206200-B1
titleOfInvention Human cholinesterase-type proteins and their production
abstract There is provided genetically engineered protein having human ChE activity, and more particularly the activity of human AChE or human pseudo-ChE. There are provided DNA sequences encoding such proteins, and more specifically DNA sequences comprising the entire coding region for encoding such complete proteins, and DNA expression vectors comprising such sequences. There is provided DNA, which has been joined outside living cells, capable of infecting culturable cells, to be maintained therein and in progenies thereof which is adapted to encode such active proteins. The invention further provides culturable cells infected with recombinant DNA defined above, and to purified proteins having human ChE activity produced by such cells. There are further provided antibodies interacting with human AChE and pseudo-ChE and assays based on the use of such antibodies. The invention also provides compositions counteracting the effects of succinylcholine and of OP compounds. containing as active ingredient an effective dosage of proteins defined above.
priorityDate 1985-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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