| abstract |
Piperazine derivatives have the general formula (I), in which R1, R2 and R3 are identical or different and represent hydrogen, C1-C6-alkyl, C3-C7-alkoxyalkyl, aryl, aryl-C1-C6-alkyl or aryloxy -C1-C6-alkyl, R4 represents C1-C4-alkoxy substituted entirely or for the most part with fluorine, R5 represents aryl, heteroaryl, aryl-C1-C4-alkyl, heteroaryl-C1-C4-alkyl, diaryl-C1- C4-alkyl, heteroaryl-aryl-C1-C4-alkyl or di-heteroaryl-C1-C4-alkyl. These derivatives and their salts constitute new compositions for the treatment and prophylaxis of diseases due to circulation disorders. |