| abstract |
A compound of formula In in which formulan R 1 and R 2 , which may be the same or different, each represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms or, together with the nitrogen atom to which they are attached, R 1 and R 2 form a 4 to 8-membered ring which may contain an oxygen atom or another nitrogen atom, which nitrogen atom may have an alkyl group having from 1 to 4 carbon atoms as substituent. X represents an oxygen atom or a group NR 4 in which R 4 represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms, a phenyl group or a phenalkyl group, the alkyl moiety of which has from 1 to 4 carbon atoms. an alkyl, phenyl or phenalkyl group being unsubstituted or substituted, or R 4 represents a nitrogen protecting group; m represents an integer of from 1 to 4; n represents the integer 1 or 2; and R 3 represents a group of formula II, III, IV, V or VIn n in which formulae R 5 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms; and R 6 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, an alkenyl group having from 2 to 4 carbon atoms, or an alkynyl group having 3 or 4 carbon atoms has histamine H-2 antagonist activity, and may be used to produce medicaments. |