| abstract |
New acylamine-peniccilin antibiotics of general formula I were synthesized and a process for their preparation was developed. in which R has the following structure: where R 3 is hydrogen, lower alkyl, alkoxycarbonyl or phenyl; R 4 , R 5 , R 6 mean separately or together hydrogen, lower alkyl radical, halogen or lower alkoxyl radical; A is an oxygen atom or N-lower alkyl group; n has the value 0 or 1; R is hydrogen or a hydroxyl group and R 2 is metal or a carboxy protecting group.n n n These antibiotics have a high antimicrobial activity against gram-positive and gram-negative microorganisms. |