| abstract |
A method of labeling amine-containing compounds, such as proteins, with a metal, particularly technetium 99m, comprises reacting metal ions in an acidic medium with a compound represented by formulas (I) or (II), wherein R1, R2 and R3 are independently selected from hydrogen, alkyl, substituted acoyl, aryl, alkanyl, etc. to form an intermediate reactive compound. This intermediate reactive compound is then reacted with the compound containing the amine to be labeled. This type of labeled amine-containing compounds have beneficial properties for immune diagnosis and therapeutic applications, especially when used in vivo. |