| abstract |
The invention relates to new racemic and optically active 12b-substituted 1-hydroxymethyl-octahydroindolo[2,3- alquinolizine derivatives of formula (I)n whereinn R' and R 2 are the same or different and represent hydrogen, halogen, nitro, amino, hydroxyl, alkyl having from 1 to 6 carbon atoms or alkoxy having from 1 to 6 carbon atoms; R 3 and R 5 are the same or different and represent hydrogen, alkyl having from 1 to 6 carbon atoms or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety; R 4 is alkyl having from 1 to 6 carbon atoms, aryl or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety; R 6 is hydrogen or alkyl having from 1 to 6 carbon atoms, aryl or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety, and the isomers and acid addition salts thereof. The compounds of the invention are valuable as intermediates in the preparation of pharmaceutically active compounds and are pharmaceutically active themselves. |