| abstract |
Mitomycin derivatives of the formula:-wherein X is[wherein R<sub>3</sub> is alkyl, cycloalkyl or optionally substituted phenyl; and R<sub>4</sub> is alkyl or cycloalkyl]; n is an integer of 2 to 8; one of R, and R<sub>2</sub> is a hydrogen atom and the other is a carbamoyloxymethyl group, or alternatively R, and R<sub>2</sub> may be combined together to form a methylene group (=CH<sub>2</sub>); and Y and Z independently represent hydrogen or methyl; exhibit anti-bacterial and anti-tumour activities. |