| abstract |
@ For the treatment of various diseases including autoimmune diseases such as myathenia gravis, articular rheumatism, lupus erythematosus, etc., immunity-related diseases such as glumerulonephritis, bronchial asthma, polyneuritis, etc., organ transplantation such as transplanted kidney rejection, AOB incompatibibity bone marrow transplantation, etc., tumor, hypertension, and hepatic insufficiency, immunoglobulin adsorbents comprising a hydroxyl-containing water-insoluble carrier to which a diamine compound having the general formula: n wherein n is an integer having a value of 3 to 9 is attached through a silane coupling agent or a derivative thereof, to which diamine a heterocyclic compound is attached through a difunctional reagent, are useful as they can selectively and efficiently adsorb specific proteins such as immunoglobulins and immune complexes which are pathogenic substances in the diseases, exhibit minimized non-specific adsorption, and are safe and easy to sterilize. |