| abstract |
The present invention relates to new asymmetric heterocyclic ester derivatives of 1,4-dihydropyridine-3,5-dicarboxylic acids of the formula: <IMAGE> (I) wherein R1 is a C1-C4-alkyl group; X and Y, which are identical or different, each represent O or S, at least one of the symbols X and Y being different from S; n is an integer equal to 1 or 2; and R2 and R3, which are identical or different, each represent H, CH3, CF3, C6H5 or halogenophenyl, it being possible for R2 and R3, taken together, to form a 5-membered to 7-membered spirocycloaliphatic group with the C atom of the heterocyclic group to which they are bonded; and their optical iomers and diastereoisomers. These new derivatives are useful as pharmaceuticals, in particular as vasodilators. |