| abstract |
A family of propylene amine oxime ligands has the formula 2n wherein preferably R 1 is C1-C4 alkyl or phenyl and each of R, R 2 , R 3 and R 4 is H or C1-C4 alkyl. The technetium-99m complexes of these ligands are lipophilic neutral complexes useful as diagnostic radiopharmaceuticals and particularly for brain scanning. The ligands show stereoisomerism. The preparation and properties of the d1- and mesostereoisom- ers, and of the d- and 1-enantiomers, are described. The 1-enantiomer and the d1-stereoisomer of the preferred compound (2, R=R 1 =R 2 =CH 3 , R 3 = R 4 = H ) show good retention in the brain. |