| abstract |
A novel sulfone compound represented by the general formula (II)wherein R' is cyclohexyl, phenyL; or a phenyl substituted with a group selected from nitro, C<sub>1</sub>-C<sub>3</sub> alkyl, C<sub>1-</sub>C<sub>3</sub> alkoxy and halogen; R<sup>2</sup>, R<sup>3</sup>, R<sup>4</sup> and R<sup>5</sup> are respectively hydrogen, halogen, cyano or carbonyl, wherein R' and R<sup>2</sup> may form an o-phenylene or an o-phenylene substituted with at least one group selected from nitro C<sub>1</sub>-C<sub>3</sub> alkyl, C<sub>1</sub>-C<sub>3</sub> alkoxy and halogen; X is oxygen or methylene; Y is -(CH<sub>2</sub>)<sub>n</sub>-, wherein n is an integer of 0, 5 or 6, orwherein m is an integer 1-3; R<sup>6</sup> is hydrogen, C<sub>1</sub>-C<sub>3</sub> alkyl, ω-alkylaminoalkykl, wherein each alkyl has 1-3 carbon atoms, or ω-dialkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms; R<sup>7</sup> is hydrogen: or C<sub>1</sub>-C<sub>3</sub>. alkyl; and R<sup>6</sup> and R<sup>7</sup> may farm 5 ring together with N, orwheren R<sup>B</sup> is hydrogen, C<sub>1</sub>-C<sub>3</sub> hydroxyalkyl or phenyl; or a pharmaceutically acceptable salt thereof is disclosed. The compound has anti-ulcer effect. |