| abstract |
A compound of the formulan nwherein X has the formula -CR 5 = CR 6- , -C≡C- or CH 2 n CR 5 CR 8 , wherein ring a is phenyl, naphthyl or heterocyclic; wherein R 1 is hydrogen, alkyl, alkanoyl or aroyl; wherein R 2 , R 3 and R 4 , which may be the same or different, each is an electron withdrawing substituent or each is hydrogen or alkyl, alkoxy or dialkylamino, provided that when ring A is phenyl or naphthyl at least on of R 2 , R 3 and R 4 is an electron-withdrawing substituent; wherein R 5 and R 6 , each is hydrogen, halogeno or alkyl; wherein R 7 is alkyl or halogenoalky; and wherein R 6 has the formula -Y-Q-R 9 where Y is straight- or branched-chain alkylene or alkenylene; wherein 0 is -O-. -S-, -SO- or -SO 2 -; and wherein R 9 is alkyl of up to 6 carbon atoms which contains one or more defined substituents, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess antiandrogenic activity and may be used in the treatment of androgendependent disease conditions such as prostatic disease, acne, hirsutism or seborrhoea. |