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filingDate 1983-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1989-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1989-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0192288-B1
titleOfInvention Steroids substituted at position 17 by a nitromethylene radical, and their use in the preparation of biologically active compounds
abstract A novel nitromethylation composition comprising nitromethane and a catalytic amount of a bifunctional basic catalyst, optionally in an organic solvent, a method of nitromethylating ketonic compounds with said compositions and novel steroids of the formulae <IMAGE> I and <IMAGE> I' wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted with an oxygen or nitrogen group or halogen and alkenyl and alkynyl of 2 to 4 carbon atoms, R2 is alkyl of 1 to 4 carbon atoms and the A,B,C and D rings optionally contain at least one double bond and optionally substituted with at least one member of the group consisting of -OH, =0, halogen, alkyl and alkoxy of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms and their use to form the corresponding 21-acetoxy-20-ketocorticosteroids compounds in a simple manner.
priorityDate 1982-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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