| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6ac661be0b9a884290451af2b1432123 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-555
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-06 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-545 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-195
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-555
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-74 |
| filingDate |
1985-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d6fabfc378be3c04e742778f448f25a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b92ea34b64a69bb1dd9f65138493870f |
| publicationDate |
1986-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0191827-A1 |
| titleOfInvention |
METHOD FOR THE REMOVAL OF N-ENDAMINOIC RESIDUES FROM EUKARYOTPOLYPEPTIDE PLANTS AND POLYPEPTIDES PRODUCED THEREFORE. |
| abstract |
A method of sequentially eliminating one or more residual amino acids from an analog of a eukaryotic polypeptide synthesized in a foreign host includes contacting the eukaryotic polypeptide analog with aminopeptide under suitable conditions allowing elimination of N-terminal residual amino acids, while the polypeptide analog contains a residual amino acid or sequence thereof that blocks the action of an aminopeptide located elsewhere than the N-terminus of the polypeptide analog. A preferred embodiment involves the removal of residual N-terminal methionine and adjacent residual leucine from a growth hormone analog produced in bacteria by contacting the growth hormone analog with aeromonas aminopeptidase under appropriate conditions allowing the elimination of N-terminal methionine and residual leucine. The invention also relates to the eukaryotic polypeptide analogs obtained by this method. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5783413-A |
| priorityDate |
1984-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |