http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0189555-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0123feaad3aab4e0b60eb15032dbe2a0 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-935 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-935 |
| filingDate | 1985-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bbd14eb4922d1f4dbcbad00f3ed9f59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d335f9cedbfa10425c6e871e13ccdc1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e5eeb47395edbfd49f4672150ef67fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc1d6d85504618a8c5406e27c7f1eb01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be42d6cc6570c425730545af5353f83f |
| publicationDate | 1986-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0189555-A1 |
| titleOfInvention | Method of obtaining derivatives of 4-beta-(1'-alken-1'-yl)-2-xi, 5-alpha-dihydroxy-3,3a-beta, 4,5,6,6a-beta-hexahydro-2H-cyclopenta[b] furane, and sulphonyl derivatives of 2H-cyclopenta[b] furane |
| abstract | A new method has been developed for obtaining derivatives of 4β-/1'-alken-1'-yl/-2ξ;, 5a-dihydroxy-9,3aβ.4.5,8.8aβ-hexahydro-2H-cyclopenta [b] furane useful in the aynthesis of prostaglandins or their analogs, and a method for obtaining new sulphonyl starting compounds of the general formula 4, in which Z denotes a hydrogen atom or a protective group, Y denotes a group of the formula =CHOZ 1 , in which Z 1 has the meaning stated for Z, whereby protective groups Z and Z 1 may be the same or different, and Ar denotes optionally a substituted aryl group. n In the method according to the invention the new sulphonyl derivative of the general formula 4 is alkylated with an electrophilic agent comprising: carbonyl derivatives, oxiranes and halohydrins or their derivatives; the alkylation product is transformed into derivatives of 4β-1'-alken-1'-yl/ -2ξ, 5a-dihydroxy-3, 3aβ, 4,5,6,6aβ-hexahydro-2H-cyclopenta [b] furane in reactions which ensure obtaining a double bond C 13 - C 14 . n New sulphonyl initial compounds of the general formula 4 are obtained from lactone of the general formula II, in which Z has the above stated meaning and L° denotes a leaving group, which is transformed into a sulphide; the obtained lactone-sulphide is reduced to lactol, and thereafter lactol-sulphide is oxidized to the sulphonyl derivative. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102070490-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102070490-A |
| priorityDate | 1984-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 164.