http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0189103-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184 |
| filingDate | 1986-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1991-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1991-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0189103-B1 |
| titleOfInvention | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates |
| abstract | The present invention provided pyrrolobenzimidazoles or tautomer thereof, of the general formula: <IMAGE> (I) wherein R1 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl or C3-C7 cycloalkyl; R2 is hydrogen, cyano, C1-C6 alkyl, C2-C6 alkenyl, or a carbonyl group substituted by hydroxyl, C1-C6 alkyl, C1-C6 alkyoxy, amino, C1-C6 alkylamino, C2-C12 dialkylamino or hydrazino, or R2 and R1 together with the carbon to which they are attached form a C3-C8 spirocycloalkyl ring, or R1 and R2 together form C3-C7 alkylidene or C3-C7 cycloalkylkidene, X is a valency bond, C1-C4 alkylene or vinylene and T is oxygen or sulphur; and Het is furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, thiadiazolyl, pyrazinyl, pyrimidinyl or pyridazinyl wherein the heterocyclic five- and six-membered rings are unsubstituted or substituted by one or more C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, hydroxyl, oxo, nitro, amino, halo, carboxyl, C2-C7 alkoxycarbonyl, aminocarbonyl or cyano groups; or a physiologically acceptable salt thereof with an inorganic or organic acid. These compounds are useful for treating heart or circulatory diseases, especially those which respond to a change of blood pressure, an increase in cardiac output and/or a change in micro-circulation. |
| priorityDate | 1985-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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