http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0189094-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C205-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4425 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4418 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-425 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-22 |
| filingDate | 1986-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49ae623817ed3d534ec8c1d6d01080c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6501518aa9822e4d93a00de5e8872a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a08b55fc61025ad21c43b007cc310d29 |
| publicationDate | 1986-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0189094-A2 |
| titleOfInvention | Polycyclic salts |
| abstract | A- das Anion einer starken organischen oder anorganischen Säure ist, XN + durch R', R' und R 3 substituiertes Pyridinium, Pyrimidinium, Thiazolium oder Imidazolium, n, q und r die Zahl 1 oder 0 und p eine ganze Zahl zwischen 1 und 15, Y die Gruppe CH 2 , C(H,OH) oder C(O), Z O, S, CH 2 , C(O), NQ', SO 2 , C(O)O, OC(O), C(O)N(O') oder N(Q')C(O), L durch R 4 substituiertes p-Phenylen und M durch R 5 und R 6 substituiertes Phenyl ist, T eine der für Z möglichen Bedeutungen hat oder C(CH 3 ) 2 C 2 H 4 , C(Q 2 )=C(Q 3 ), C≡C, CH 2 C(O), C(O)CH 2 , CH 2 O oder OCH, ist, R' eine Gruppe Ar, Ar-C 1-4 -Alkyl, ArO oder ArC(O), Ar durch R', R 8 und R' substituiertes Phenyl, R 2 und R 3 H, C 1-4 Alkyl, C 1-4 Alkouy oder C 5 H 5 , wobei das N-Atom in 2-Stellung einer Imidazoliumgruppe XN + durch Ar, Ar-C 1-4 -Alkyl oder C 1-4 -Alkyl substituiert sein muss, R 4 bis R' H, Halogen, CF 3 , NO 2 , CN, C 1-4 -Alkyl, -Alkoxy, --Alkylthio oder -Alkylsulfonyl), SO 2 N(R,Q), C(O)N(Q 4 Q 5 ), C-(O)Q 4 , C(O)OQ 4 oder OC(O)Q 4 , R, Q, Q 1 , Q 2 und Q' H oder C 1-4 -Alkyl, und Q 4 und Q 5 C 1-4 -Alkyl sind, hemmen die intestinale Resorption des Cholesterins und der Gallensalze im enterohepatischen Kreislauf. Man kann diese ein quaternäres N-Atom erhaltende Salze ausgehend von entsprechenden Aminen herstellen. Polycyclic salts of the formula if A- is the anion of a strong organic or inorganic acid, XN + pyridinium, pyrimidinium, thiazolium or imidazolium substituted by R ', R' and R 3 , n, q and r are the number 1 or 0 and p is an integer between 1 and 15, Y is the group CH 2 , C (H, OH) or C (O), ZO, S, CH 2 , C (O), NQ ', SO 2 , C (O) O, OC (O), C (O) N (O') or N (Q ') C (O), L substituted by R 4 p-phenylene and M is phenyl substituted by R 5 and R 6 , T has one of the possible meanings for Z or C (CH 3 ) 2 C 2 H 4 , C (Q 2 ) = C (Q 3 ), C≡C, CH 2 C (O), C (O) CH 2 , CH 2 O or OCH, R 'is an Ar, Ar-C 1-4 alkyl, ArO or ArC (O) group, Ar substituted by R ', R 8 and R' phenyl, R 2 and R 3 H, C 1-4 alkyl, C 1-4 alkouy or C 5 H 5 , where the N atom in the 2-position of an imidazolium group XN + by Ar, Ar-C 1-4 alkyl or C 1-4 alkyl must be substituted, R 4 to R 'H, halogen, CF 3 , NO 2 , CN, C 1-4 alkyl, alkoxy, alkylthio or alkylsulfonyl), SO 2 N (R, Q), C (O) N ( Q 4 Q 5 ), C- (O) Q 4 , C (O) OQ 4 or OC (O) Q 4 , R, Q, Q 1 , Q 2 and Q 'H or C 1-4 alkyl, and Q 4 and Q 5 are C 1-4 alkyl, inhibit the intestinal absorption of cholesterol and bile salts in the enterohepatic circulation. These salts, which contain a quaternary N atom, can be prepared starting from appropriate amines. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008116145-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008116145-A3 |
| priorityDate | 1985-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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