http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0186431-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d269c8e41f178194d858c230c9f85e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0222 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 |
| filingDate | 1985-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84204e87d43cb555c7829727c22cabd3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5280a6b506397483dfaabc53c2e3b707 |
| publicationDate | 1986-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0186431-A1 |
| titleOfInvention | Anti-hypertensive octahydro-6-azaindole dipeptide derivatives |
| abstract | Octahydro-6-azaindole dipeptide derivatives are inhibitors of angiotensin converting enzyme, useful for the treatment of hypertension and have the formula: n<CHEM>n wherein:n R<1> is H, C1-C6 alkyl, C2-C6 alkenyl or aryl-(C1-4 alkyl);n R<2> is C1-C6 alkyl C2-C6 alkenyl, C3-C7 cycloalkyl or substituted C1-C6 alkyl in which the substituent is halo, hydroxy, C1-C6 alkoxy, aryl, aryloxy, aryl-(C1-C4 alkoxy), C3-C7 cycloalkyl, -NR<5>R<6>, -NHCOR<5>, -NHCO2R<7> guanidino, C1-C4 alkylthio, arylthio, aryl-(C1-C4 alkyl)thio or a heterocyclyl group;n R<3> is C1-C6 alkyl, C3-C7 cycloalkyl or a substituted C1-C6 alkyl group in which the substituent is -NHCOR<5>, -NHCO2R<7>, -NR<5>R<6>, hydroxy, halo, -CONR<5>R<6>, C3-C7 cycloalkyl, guanidino, -CO2H, -CO2(C1-C4 alkyl), C1-C4 alkoxy, C1-C4 alkylthio, aryl or a heterocyclyl group;n R<4> is -COR<5>, -CO2R<7>, -SO2R<7>, -SO2NR<5>R<6>, -CONR<5>R<6>, -CON(R<5>)SO2R<7> or -CON(R<5>)COR<7>,n wherein R<5> and R<6> are each independently H, C1-C6 alkyl, C3-C7 cycloalkyl, aryl, heterocyclyl or a substituted C1-C6 alkyl group in which the group is substituted by one or more halo atoms or a hydroxy, C3-C7 cycloalkyl, aryl, heterocyclyl or -NR<8>R<9> group wherein R<8> and R<9> are each independently H, C1-C4 alkyl, -CO(C1-C4 alkyl) or aryl; or the two groups R<5> and R<6> when attached to nitrogen may be taken together with the nitrogen atom to form a pyrrolidinyl, piperidino, morpholino, piperazinyl or N-(C1-C4 alkyl)-piperazinyl group; and R<7> is as defined for R<5> but not including hydrogen. |
| priorityDate | 1984-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 243.