| abstract |
The alpha, omega-dicarboxylic acids of formula (I ') in which: R1 and R2, identical or different, represent a lower alkyl group, substituted or not substituted by hydroxy, lower alkoxy, halogen or phenyl, the phenyl group possibly being substituted one or more times with hydroxy, lower alkoxy, lower alkyl or halogen; a lower alkenyl or alkinyl group; a C3-C7 cycloalkyl group or a phenyl group optionally substituted by hydroxy, halogen, lower alkyl or lower alkoxy. X and Y, which may be the same or different, represent hydrogen, lower alkyl, lower alkoxy, hydroxy, cyano, halogen, carboxyl, lower alkoxy carbonyl or carbamoyl and Q represents an unbranched, saturated or unsaturated chain, with 8 to 14 atoms carbon which may be substituted, interrupted by hetero atoms and form part of a ring system, as well as their carboxylic acid derivatives hydrolyzable in vivo, provided that when Q represents an alkylene chain with 8-14 C atoms, unbranched, saturated and R1 and R2 represent methyl and Y hydrogen, X does not represent hydrogen, ethoxy carbonyl, bromine, cyano or methyl, and when R1 and R2 are methyl and X and Y are hydrogen, Q does not represent a group of formula (II). Process for their preparation and medicaments containing these compounds which have an anti-diabetic action and lower the level of lipids. |