http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0183369-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8659631bf38b3a590c0d3edc265492c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-473 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 1985-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e874256c5d765276af5be0a1df6ed628 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a05a8e6e2e8d543d85839404e06de7d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fddfdec96116fe1f82ffdc5c0b506ae2 |
| publicationDate | 1986-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0183369-A2 |
| titleOfInvention | Dihydroisoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them |
| abstract | Compounds of the general formula In nin which:n R, and R 2 are independently hydrogen, C, 6 alkyl ortogether are a group X which is C 3 6 polymethylene optionally in which one carbon atom is replaced by O, S or NR 6 wherein R 6 is hydrogen or C 1 6 alkyl; R 3 is a mono- or fused bi-cyclic heteroaromatic group having up to ten atoms in the aromatic ring(s), not more than four of which are selected from nitrogen, oxygen or sulphur, optionally C-substituted by one or more substituents selected from halogen, CF 3 , nitro, C 1-6 alkoxy, C 1-6 alkylthio, C 2-7 alkanoyl or cyano; or is phenyl or naphthyl, optionally substituted by one or more substituents selected from halogen, CF 3 , nitro, C 1-6 alkyl, C 1 6 alkoxy, C 1 6 alkylthio, C 2-7 alkanoyl, carboxyl, C 1-6 alkoxycarbonyl, cyano, CONR 7 R 8 wherein R 7 and R 8 are selected from hydrogen or C 1-6 alkyl or together are a group X; NR 9 R 10 wherein R 9 and R 10 are selected from hydrogen, C 1-6 alkyl, C 2 - 7 alkanoyl or C 1-6 alkylsulphonyl or together are a group X; SO 2 NR 11 R 12 wherein R 11 and R 12 are selected from hydrogen or C 1-6 alkyl or together are a group X; or S(O) m R 13 wherein m is 1 or 2 and R 13 is C 1-6 alkyl; Z is naphthyl or a mono- or fused bycyclic heteroaromatic ring having up to ten atoms in the aromatic ring(s), not more than four of which are selected from nitrogen, oxygen or sulphur or (when R 3 is an optionally substituted naphthyl or heteroaromatic group as defined) Z is a phyenyl ring; and Z is optionally C-substituted by one or two substituents R 4 and R 5 which are independently selected from C 1-6 alkyl, cyano, amino, aminocarbonyl or aminocarbamoyl optionally substituted by one or two C 1-6 alkyl groups or by a group X, halogen, CF 3 , nitro, C 1-6 alkoxy, C 1-6 alkylthio, C 2-7 alkanoyloxy or hydroxy, or together on adjacent carbon atoms are methylenedioxy or C 3-5 polymethylene, are disclosed as an active therapeutic substances for the treatment of inflammatory conditions. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4970316-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0428878-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0428878-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-583063-B2 |
| priorityDate | 1984-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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