| abstract |
A compound of the formula:n wherein Y is a free or esterified carboxyl group, or a group of the formula:n (wherein R a and R b are each independently a hydrogen atom, a C 1 -C 4 alkyl group, a C 3 -C 7 cycloalkyl group, a benzyl group, a phenyl group, a phenyl group substituted with a halogen atom or a C 1 -C 4 alkyl group, or, when taken together with the adjacent nitrogen atom, they represent a 5 to 7 membered saturated heterocyclic goup); R' is a C 1 -C 12 alkyl group, a C 2 -C 12 alkenyl group, a C 2 -C 12 alkynyl group, a C 3 -C 10 cycloalkyl group, a C 4 -C 10 cycloalkenyl group, a hydroxy C 1 -C 13 alkyl group, an C 1 -C 12 alkyl group substituted with a group of the formula:n (wherein R c and R d are each independently a hydrogen atom, or a C,-C 4 alkyl group), a C 3 -C 10 heterocyclic group, a phenyl group optionally substituted with one to three substituents selected from the group consisting of halogen atom, hydroxyl group, C 1 -C 4 alkyl group, trifluoromethyl group, C 1 -C 4 alkoxy group, and group of the formula:n (wherein R c and R d are as defined above) or a group of the formula:n [wherein A is a C 1 -C 7 alkylene chain and B is a C 3 -C 10 cycloalkyl group, a C 4 -C 10 cycloalkenyl group, a C 1 -C 12 alkoxy group, a C 1 -C 12 alkylthio group, a C 3 -C 10 cycloalkoxy group, a C 4 -C 10 cycloalkenyloxy group, a C 3 -C 10 heterocyclic group, or a phenyl or phenoxy group optionally substituted with one to three substituents selected from the group consisting of halogen atom, hydroxy group, C 1 -C 4 alkyl group, group of the formula:n (wherein R c and R d are as defined above), trifluoromethyl group, C 1 -C 4 alkylthio group and C,-C 4 alkoxy group]; n is 2, 3 or 4; R 2 and R 3 are hydrogen atoms or, when taken together, they mean a single linkage to form a trans double bond between the adjacent carbon atoms, and E is a cis or trans vinylene group; provided that when n is 3 and R' is a n-octyl group, a 2-octenyl group or a 2,5-octadienyl group, R 2 and R 3 are hydrogen atoms, and that when n is 2, E is a trans vinylene group or a non-toxic pharmaceutically acceptable salt thereof. Said compound have potent anti-leucotriene B 4 action, and are useful in the treatment of inflammation and allergy. |