http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0181635-A3
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6827 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-82 |
| filingDate | 1985-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1988-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0181635-A3 |
| titleOfInvention | Probes and methods useful for detecting chromosomal translocations |
| abstract | A single-stranded nucleic acid molecule useful as a nprobe for detecting chromosomal translocations has a nnucleotide sequence which comprises at least one sequence npresent within an exon of a eucaryotic chromosomal gene nand complementary to the mRNA encoded by the exon, the ngene being characterized by the presence within it of at least none chromosomal breakpoint site into which another nucnleotide sequence may be translocated. In a specific embodinment the translocation is the Philadelphia translocation, the neucaryotic chromosomal gene is on human chromosome 22 nand the translocated nucleotide sequence is at least part of nthe c-abl oncogene n The invention also provides purified, hybrid mRNA nmolecules useful as indicators of chromosomal translocantions. The mRNAs are transcripts of hybrid DNA sequences npresent on aberrant chromosomes resulting from chromonsomal translocations. The invention further provides hybrid npolypeptides encoded by the hybrid mRNA molecules and nantibodies directed to antigenic determinants on these nhybrid polypeptides. n The single-stranded nucleic acid molecules, polypepntides and antibodies of this invention may be used to detect nchromosomal translocations and to diagnose diseases assonciated therewith. |
| priorityDate | 1984-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.