| abstract |
Compounds of formula (I) where A) R represents O (CH2) 2O-R3 and a) R5 represents hydrogen and R3 represents n-propyl, isobutyl, cyclopentylmethyl, benzyl or 2- (p-fluorophenyl) ethyl ; b) R1 represents a fluorine, R5 a hydrogen and R3 an n-propyl; c) R1 represents methyl, R5 represents hydrogen and R3 represents cyclopropylmethyl; d) R1 represents a cyano, R5 a hydrogen and R3 an n-propyl; e) R1 represents a hydrogen, R5 a methyl and R3 an alkyl having from 2 to 5 carbon atoms, a cycloalkylmethyl having from 5 to 7 carbon atoms in its cycloalkyl part or - (CH2) nR 'where n is 0, 1 or 2 and R 'represents phenyl or monofluorophenyl; or B) R represents hydroxy, R1 fluorine and R5 hydrogen. These compounds, their physiologically hydrolyzable derivatives in which at least one hydroxy group is in esterified form and their salts cause a block of highly cardioselective beta 1 adrenoceptor, and in most cases a cardiospecific block, and have significant cardiotonic activity. These compounds can be used as therapeutic agents. They are obtained by the 3-amino-2-oxypropylation of the respective substituted phenol. |