| abstract |
New 8-substituted nucleoside and purine derivatives of the general formula:wherein R represents an amino or an hydroxy group possibly in the corresponding keto tautomeric form, R<sub>1</sub> is hydrogen or an amino group, R<sub>2</sub> is hydrogen or a β-D-ribofuranosyl radical wherein the primary hydroxy group and/or the two secondary hydroxy groups may be derivatized, R<sub>3 </sub>is an optionally substituted aryl or monocyclic heteroaryl radical and, X is-O-or-S-.The new compounds have antihyperlipaemic activity. |