http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0174770-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c3899a93c972ce60b070fca823112248 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-80 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4418 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-71 |
| filingDate | 1985-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9d4e3c1b4e767331066fc5f95aa42a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0f311624a92dda7854e7456b3e53a45 |
| publicationDate | 1986-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0174770-A1 |
| titleOfInvention | Leukotriene antagonists, their preparation, use pharmaceutical compositions containing them and methods of making them |
| abstract | Compounds having the formula:n nand their pharmaceutically acceptable salts or acid-addition salts are antagonists of leukotrienes of C 4 , D 4 and E 4 , the slow-reacting substance of anaphylaxis, and are useful in anti-asthmatic, anti-allergic and anti-inflammatory agents.n In the formula Y is Cr or N, but at least one Y must be N; n is 0 to 6; R is H, OH, alkyl, CF 3 , alkenyl alkoxy SH, thioalkyl, possibly substituted phenyl, benzyl, phenetyl, halogen, amino, N(R 4 ) 2 , COOR 4 CH 2 OR 4 , CHO, CN, SCF 3 , or NO 2 ; R 1 is H, alkyl or alkoxy; R 2 is H, alkyl, R 4 CO, or R 4 0CH 2 ; R 3 is alkyl, alkenyl possibly substituted phenyl; R 4 is H or alkyl; R 5 is H, OH, alkyl, alkenyl or both R 5 's may be combined to create a doubly bonded oxygen (=0) or doubly bonded =C(R 4 ) 2 group; X 1 and X 2 are oxygen, S(O) m with m is 0-2;n n Z is O, S, H and OH, CH 2 , alkenyl; N-R e wherein R e is OH, N(R 4 ) 2 , alkyl, alkoxy, possibly substituted phenyl;n R a is H, OH or alkyl; p is 0 to 2; and r is 0 - 4; R 7 is COOR 4 ; CH 2 OH; CHO; tetrazole; CONHSO 2 R 9 ; NHSO 2 R 9 ; hydroxymethylketone; acetoxymethylketone; CN; CON(R 4 ) 2 ; a monocyclic or bicyclic heterocyclic ring containing an acidic hydroxyl group; orn nwherein s is independently 0 to 3; R 10 is A) a monocyclic or bicyclic heterocyclic radical, or B) the radical W-R 11 wherein W is 0, S or NH and R 11 is (1) a hydrocarbon radical or (2) an acyl radical of an organic acyclic or monocyclic carboxylic acid containing not more than 1 heteroatom in the ring; R 8 is H, or alkyl, and is absent when a triple bond is present. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0516069-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7678794-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006014918-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7803938-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1773774-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7598423-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1773774-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7858646-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7816523-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7754742-B2 |
| priorityDate | 1984-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 781.