| abstract |
The invention provides amino acid-containing therapeutic compound having the formula:n K-His-Trp-Ser-Tyr-M-Q-Arg-Pro-T, wherein K is N-Acetyl-Sarcosine or pGlu; M is D-Phe, D-Trp, D-β-Naphthylalanine, or D-4-X-Phe, wherein X is OH, F, CI, Br, or Me; Q is Leu, Phe, 4-X-Phe, Trp, or β-Naphthylamine (wherein X is OH, F, CI, Br, or Me), or an N-Me derivative thereof; and T is Gly-NH 2 , NHCH 3 , NHCH 2 CH 3 , or NHCH 2 CH 2 CH 3 ; provided that, when Q is Leu or N-Me-Leu, K cannot be pGlu; or a pharmaceutically acceptable salt thereof. |