| abstract |
The phenyl nonatetraenoic acid derivatives of the formula where R 1 is hydrogen, lower alkyl, chlorine, fluorine or trifluoromethyl; R 2 is hydrogen, lower alkoxy, trifluoromethyl-lower alkoxy, hydroxy, lower alkyl, chlorine, trifluoromethyl or fluorine; R 3 is hydrogen, lower alkyl, chlorine or fluorine; R 4 alkyl with 4-10 C atoms or -CH 2 (CH 2 ) n CH 2 OH; X -CH (Rio) O-, -CH (R 10 ) -, -O-, -C (R 10 ) = CH- or -N (R 10 ) -; R 5 COOR 9 ; n 6 or 7; and R 7 , R 8 , R 9 and R 10 denote lower alkyl or hydrogen and salts thereof, when R 9 is hydrogen, as active ingredients in anti-rheumatic, anti-arthritic and immunosuppressive agents. The compounds I can be obtained from the corresponding intermediate products by building up the Wittens polyene side chain or by introducing the radical R 4 . |