http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0168440-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cfb19d2c57ea3524c4be27d297ea15b0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-00 |
| filingDate | 1985-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4540edf26eede6eb2ead26bc2d29553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ef420695c7720cb3f6701440e7a96f2 |
| publicationDate | 1986-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0168440-A1 |
| titleOfInvention | Preparation of penicillin sulfoxide |
| abstract | Process for the preparation of penicillin V beta-sulfoxide by oxidation of penicillin V in a two-phase liquid system comprising an aqueous solution of hydrogen peroxide and an organic solvent or a mixture of organic solvents. The process is characterized by the fact that (I) the aqueous hydrogen peroxide solution is free from any organic acid promoter, has a concentration of 20 to 50% w / v H2O2 in water, and the molar ratio between H2O2 and penicillin V is between 1.5: 1 and 7: 1; (II) the organic solvent or the mixture of organic solvents cannot be mixed with water, is inert with hydrogen peroxide, can dissolve penicillin V and has a lower solubility compared to beta-sulfoxide of penicillin V than compared to penicillin V; (III) penicillin V is present in the organic solvent or mixture of organic solvents which cannot be mixed with water in the form of a concentrated solution in the range from 35 to 120% w / v. The penicillin V beta-sulfoxide thus formed crystallizes from the two-phase liquid system as oxidation continues, with relatively high yield and purity. |
| priorityDate | 1984-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.