| abstract |
A phenol derivative of the formulan wherein NU is a defined phenolic nucleus including a phenyl-hydroxynaphthyl; hydroxyphenyl-naphthyl; phenyl- hydroxyindanyl, phenyl-hydroxybenzothienyl or mono- hydroxyphenyl-ethylene or vinylene nucleus; wherein A is alkylene, alkenylene or alkynylene which may be interrupted by phenylene or other linkages, wherein R' is hydrogen, or alkyl, alkenyl, alkynyl, cycloalkyl, halogenoalkyl, alkozyalkyl, halogenoalkoxyalkyl, aryl or arylalkyl, or R' is joined to R 2 , and wherein X is -CONR 2 -, CSNR 2 -, -NR 12 CO-, -NR 12 CS-, -NR 12 CONR 2 -,n -SO 2 NR 2 - or -CO-, or, when R 1 is not hydrogen, is-NR 12 COO-,-(PO)R 2 -, -S-, -SO- or -S0 2 -, wherein R 2 is hydrogen or alkyl, or R 1 and R 2 together form alkylene; wherein R' 2 is hydrogen or alkyl, and wherein R 22 is hydrogen, cyano or nitro, or a salt thereof when appropriate. The compounds possess antioestrogenic activity and may be used for the treatment of hormone-dependent breast tumours or of anovulatory infertility. |