| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-84
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-333 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J27-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J23-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-84
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-475
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-734
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-377
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-307
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-00 |
| filingDate |
1985-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1987-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
1987-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0163338-B1 |
| titleOfInvention |
Process for preparing naproxen |
| abstract |
Process for preparing Naproxen via a sequence of a stereospecific reactions which comprises: condensation of 1-chloro-2-methoxy-naphthalene with a (S)-2-halo-propionyl halide according to the Friedel-Crafts reaction, ketalization of the thus obtained (S)-2-halo-1-(5'-chloro-6'-methoxy-2'-naphthyl)-propan-1-one, rearrangement of said ketal to aford an ester, hydrolysis of the ester and removal of the chlorine atom in 5-position by hydrogenolysis.New (S) 2-halo-1-(5'-chloro-6'-methoxy-2'-naphthyl)-propan-1-ones. |
| priorityDate |
1984-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |