abstract |
Disclosed are antibiotic 6-[1-hydroxy-ethyl]-2-SR 8 -1-methyl-1-carbadethiapen-2-em-3-carboxylic acids and their pharmaceutically acceptable salts and esters (I):n wherein: R 8 isn ;and wherein n and m are independently selected from 0, 1, 2, 3, 4; X is -NR; and Y is -R, or -NRR; and wherein R is independently selected from hydrogen, alkyl, alkenyl, alkynyl, (having 1-6 carbon atoms); cycloalkyl and cycloalkenyl (having 3-6 carbon atoms); and heterocyclyl, heteroary. (having 3-6 ring atoms, one or more of which is N, O or S). n Also disclosed are processes for the preparation of such compounds and pharmaceutical compositions comprising such compounds. |