| abstract |
Pyrrolidine, piperidine and homopiperidine- carboxamide and thiocarboxamide compounds of the formula:n wherein X is -S-, -S(0)- or -S(0) 2 -; A is a loweralkalene chain and A 1 and A 2 are alkalene chains when p and d are one; R, R 1 and R 2 are hydrogen, loweralkyl, phenyl cycloalkyl or phenylalkyl and R 1 and R 2 may form a heterocyclic residue with the adjacent nitrogen atom; Q is a selected aromatic radical, and the pharmaceutically acceptable acid addition salts are useful as cardiac antiarrhythmia agents. n Chemical intermediates, unsubstituted on pyrrolidine, piperidine and homopiperidine nitrogen but with the -(A 2 ) p -X-(A 2 ) d -Q side chain are also disclosed. |