| abstract |
The invention relates to a group of Δ<sup>4</sup>- and Δ<sup>5(10)</sup>-oestrene derivatives having an alkyl(1-4 C) substituent in position 6 or 7, an oxy substituent in position 17β and optionally an oxo- or oxy- substituent in position 3 and a hydrocarbyl(1-4 C) group in position 17a, for use as immunomodulator. The compounds are in particular suitable for therapeutic use in the treatment of auto-immune diseases. |