| abstract |
Compounds of formula I <CHEM> are valuable H-2 antagonists; R represents hydrogen, alkyl, phenyl or phenalkyl; W and Z represent groups E-(CH2)n-X-(CH2)m-NH with E being phenyl, imidazolyl, thiazolyl, furyl, thienyl or pyridyl; or W or Z is hydrogen, alkyl, phenyl, O-alkyl, NR<4>R<5>(R<4>/R<5> are hydrogen, alkyl or phenyl); X is O or S; n is 0 or 1, m is 2, 3 or 3. Moreover compounds XXXI are described <CHEM> in which R<3><1>/R<3><2> are H, alkyl. cycloalkyl, phenyl, phenylkyl or part of 4-to 7-membered ring; L<3>/L<4> are X-(alkyl-phenyl, -phenalkyl), compounds XXXI are versatile intermediates for the production of i.a. compounds I. Compounds XXXV <CHEM> with R<4><2>/R<4><3> being hydrogen, alkyl, phenyl, phenyalkyl are also versatile intermediates inter alia for the preparation of compounds I. Processes for the preparation of these compounds are disclosed as well. |