| abstract |
A 3N-substituted 3,4-dihydropyrimidine derivative of the formula:n wherein R' is methyl or ethyl, R 2 is methyl or ethyl, R is phenyl or substituted phenyl, X is chloro or methyl and pharmaceutically acceptable acid addition salts thereof have in form of pharmaceutical compositions substantially the same strong vasodilative and Ca ++ antagonistic effects as nicardipine and therefore are useful as agents for treating disorders of the cardiovascular system, for example, hypotensive agents, agents for amelioration of brain circulation and anti-angina pectoris agents. n Processes for producing the above compounds economically and effectively are also disclosed. |