| abstract |
The invention relates to isochromanes and oxepins of the general formula (I) wherein R¹ is a hydrogen atom or a straight or branched alkyl group with up to 4 carbon atoms, R² is a hydrogen atom or a straight or branched alkyl group having up to 4 C atoms or together with R¹ is an alkylene group having 3 to 5 C atoms, R³ is a hydrogen atom or a straight or branched al yl group with up to 4 C atoms, R⁴ is a hydrogen atom or a straight or branched alkyl group with up to 4 carbon atoms, R⁵ is a hydrogen atom or a straight or branched alkyl group having 1 to 6 carbon atoms or a pyridinyl group, R⁶ is a hydrogen atom, a fluorine, chlorine or bromine atom, a straight or branched alkyl group with 1 to 6 carbon atoms, a hydroxyl or alkoxy group with 1 to 4 carbon atoms or a trifluoromethyl group, R⁷ is a hydrogen atom, a fluorine, chlorine or bromine atom, a straight or branched alkyl group having 1 to 6 C atoms, a hydroxyl or alkoxy group having 1 to 4 C atoms or together with R⁶ a methylenedioxy group, R⁸ is a hydrogen atom, a hydroxyl or alkoxy group with 1 to 4 carbon atoms, m the numbers 1 or 1 and n denotes the numbers 1, 2 or 3, and their acid addition salts.n n n The compounds are calcium antagonistic and antinhypertonic. |