| abstract |
The invention relates to 1,3,5-trisubstituted 1,2,4-triazole derivatives of the general formula <IMAGE> wherein R1 represents an alkyl radical (e. Optionally by 1 or more fluorine, chlorine and / or bromine atom (s) ), Alkoxy group (s), nitro group (s), trifluoromethyl group (s), alkylthio group (s), alkylsulfinyl group (s) and / or alkylsulfonyl group (s), phenyl group or a naphthyl group, R2 is one, optionally with 1 or more fluorine -, chlorine and / or bromine atom (s), alkyl radical (s), alkoxy radical (s), nitro group (s), trifluoromethyl radical (e), alkylthio radical (e), alkylsulfinyl radical (s) and / or alkylsulfonyl radical (s), Phenyl radical or a thienyl radical, R3 is an alkyl radical optionally substituted by 1 or more fluorine and / or chlorine atom (s), hydroxyl group (s), alkoxycarbonyl radical (s), cyano group (s) and / or pyridyl radical (s), one Alkoxycarbonylrest, an oxoalkyl radical or a phenylalkyl radical substituted in the phenyl ring by 1 or more fluorine and / or chlorine atom (s) ellen and n is 0, 1 or 2. The invention also relates to a process for the preparation of these compounds and medicaments containing them, in particular with anti-inflammatory and anti-rheumatic activity. |