http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0148010-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56666880a5e2b7703e98a4f9b2d9daf6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-937 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-935 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-937 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-557 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 1984-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_430f1ae27775ef72863b38ee9f4771a8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_102715c3f1afdd60f22d7eae29986e45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbe40e6bb34d496ed14d15f1d31d180b |
| publicationDate | 1985-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0148010-A2 |
| titleOfInvention | 5-Fluoro-3-oxa-prostacyclin compounds |
| abstract | 5-Fluoro-3-oxa-prostacyclin (PGl<sub>2</sub>) derivatives of Formula I, useful for the treatment of platelet dysfunction, atherosclerosis, hypertension and tumor cell metastasis, are prepared.R' is:a) a pharmaceutically acceptable cationor b) OR<sup>1</sup> is NR<sup>3</sup><sub>2</sub>, where R<sup>3</sup>=H, methyl, ethyl, propyl, isopropyl or a combination of these groups;or c) C<sub>1</sub>-C<sub>6</sub> alkylord) HR<sup>2</sup> isa) a C<sup>1</sup>-C<sup>8</sup> aliphatic hydrocarbon group; a 1-8 alkyl optionally containing 1 or 2 unsaturated bond(s) and optionally substituted by methyl, dimethyl or F;or b) a cycloaliphatic carbocyclic compound of 4-7 ring carbons having optionally 1 unsaturated bond and having optionally 1 ring carbon replaced by S or 0;or c) phenyl;or d) benzyl;or e) -(CH<sub>2</sub>)<sub>M</sub>-R<sup>4</sup> wherein m is 0 or an integer of 1-6 and R<sup>4</sup> is alkoxy or cycloalkyl;wherein the OH on carbon 15 may optionally be on carbon 16 instead; wherein the dotted line between C<sub>5</sub> and C<sub>6</sub> and between C<sub>6</sub> and C<sub>7</sub> is one optional double bond and wherein X=H, OCH<sub>3</sub> or OC<sub>2</sub>H<sub>5</sub> when neither C<sub>5</sub>-C<sub>6</sub> nor C<sub>6</sub>-C<sub>6</sub> is a double bond and nothing if either C<sub>5</sub>-C<sub>6</sub> or C<sub>6</sub>-C<sub>7</sub> is a double bond. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0190620-A1 |
| priorityDate | 1983-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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