http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0140684-A2
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c3899a93c972ce60b070fca823112248 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-93 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C381-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-00 |
filingDate | 1984-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0f311624a92dda7854e7456b3e53a45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9d4e3c1b4e767331066fc5f95aa42a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28af72da5e66be21a8b65260accc2352 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3d5f2279431289ce488e875a4d7b69a |
publicationDate | 1985-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-0140684-A2 |
titleOfInvention | Leukotriene antagonists |
abstract | Compounds having the formula:n and their salts, including acid-addition salts, are novel. These compounds are antagonists of leukotrienes of C 4 , D 4 and E 4 , the slow reacting substance of anaphylaxis. The compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents and are made into suitable pharmaceutical compositions.n In the formula, each R, independently of the other(s), is H, OH or OR 2 , or C(R) 2 represents C=C(R 4 ) 2 ; R 1 is H, OH, acyl, formyl, R 5 CO; or R 5 OCO; each of R 2 and R 3 , independently of the others, is H, OH, C 1-6 alkyl, C 2-6 alkenyl, trifluoromethyl, C 1-6 alkoxy, SH, C 1-6 thioalkyl, phenyl, phenyl having C 1-3 alkyl halogen substitution, benzyl, phenethyl, halogen, amino, N(R 4 ) 2 , COOR 4 , CH 2 0R 4 , formyl, CN, trifluoromethylthio or nitro; .each of X 1 and X 2 , independently of the other, is oxygen, sulfur, sulfoxide, sulfone, -SO=NR 5 , NR e , N-CO-R 7 , N-CN or NCONHR 6 ; each of R 4 and R 6 , independently of the other(s), is H or C 1-6 alkyl; each R 5 is C 1-6 alkyl; each R 7 , independently of the other, if any, is C 1-6 alkyl or C 1-6 alkoxy; W is H or C 1-6 alkyl or is combined with Y to form an unsaturated bond; Z is H, OH or C 1-6 alkoxy, or is combined with Y to form an oxo residue; Y, of not combined with Z or W, is hydrogen; A is -[C(R 4 ) 2]s- R 8 where S is 0,1, 2, or 3 and R 8 isCOOR 4 , CH 2 0H, CHO, tetrazolyl, NHSO 2 R 9 , CONHSO 2 R 9 , hydroxymethylketone, CN, CON(R 7 ) 2 , a monocyclic heterocyclic ring containing an acidic hydroxyl group, orn where each s, independently, of the others, is 0, 1, 2 or 3 and R 10 is (A) a monocyclic or bicyclic radical containing from 3 to 12 nuclear carbon atoms and, as nuclear heteroatoms, two Ns or one N and one S, and with each ring in the heterocyclic radical being formed of 5 or 6 atoms, or (B) the radical X'-R 11 where X' is O, S or NH and R 11 contains up to 21 carbon atoms and is a hydrocarbon radical or an acryl radical of an organic acyclic or monocyclic carboxylic acid containing not more than 1 heteroatom in the ring; each n, independently of the others, is 0,1, or 3; R 9 is OH, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 perfluoroalkyl, phenyl, or phenyl having one or more R 2 substituents. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AP-83-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0448274-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2079997-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2546232-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5410054-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0544488-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9420480-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0288202-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0448274-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0544488-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0154684-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0206741-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5968958-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5462954-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4885309-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0288202-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-1035001-C http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0275667-A1 |
priorityDate | 1983-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 765.