| abstract |
Compounds of formula (I):n or a pharmaceutically acceptable salt, ester or amide thereof, wherein:n Ar is benzofuran-2-yl, or phenyl optionally substituted by groups R' and/or R 2 wherein R' is halogen, trifluoromethyl or hydroxy and R 2 is halogen; R 3 is hvdrogen or methyl; Xis-n in which a is an integer from 1 to 6, b is an integer from 2 to 7, M is hydroxy, C 1-6 alkoxy, phenyl C 1-6 alkoxy, or-NR 4 R 5 in which R 4 and R 5 are each hydrogen or C 1-6 alkyl or together form a five or six membered heterocyclic ring; Y is C 2-6 straight or branched alkylene, with at least two carbon atoms between the -O- and -OH; and n is 1 or 2, having anti-obesity and/or anti-hyperglycaemic activity, pro- cessesfortheir preparation and their pharmaceutical use. |