http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0138533-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c3899a93c972ce60b070fca823112248 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D337-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D337-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D337-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D337-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C63-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D337-00 |
| filingDate | 1984-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0f311624a92dda7854e7456b3e53a45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_727dce187dd23a64a02d43b3a9e2a50a |
| publicationDate | 1985-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0138533-A2 |
| titleOfInvention | 6H-dibenz(b,f)thiepin compounds |
| abstract | Novel dibenz[b,flthiepin derivatives have the formula n wherein n is 1 or 2;n the broken lines represent optional double bonds; Z is thio, sulfinyl or sulfonyl; each of R 2 , R 3 and R 9 , independently of the others, is a hydrogen or halogen atom or a nitro, lower alkyl, amino, N-(lower alkyl)amino, N,N-di(lower alkyl)amino, lower alkanoyl, hydroxy, lower alkoxy, lower acyloxy, lower alkylthio, trifluoromethylthio, lower alkylsulfinyl, lower alkylsulfonyl ortri- fluoromethyl radical, or R 2 and R 3 together represent a doubly bonded oxygen; and R 1 is (a) 5-tetrazoyl, 5-tetrazoylmethyl, 3-hydroxy-1,2,5-thia- diazol-4-yl, 4-hydroxy-Δ 3 -pyrrolin-3-yl-2,5-dione orn where m is 0, 1,2,3 or 4 and R 4 is hydroxy, lower alkoxy, N,N-di(lower alkyl)aminolower alkoxy), lower hydroxyalkyl, lower carboxylalkoxy, amino, N-(lower alkyl)amino, N,N-di(lower alkyl)amino, lower alkylsulfonylamino, carboxy(lower alkyl)-amino, carboxamido(lower alkyl)amino, 2-imino-3-methylthia zolidine, (lower acyloxy)-(lower alkoxy) or (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy (b) -CHO or a prodrug derivative of an aldehyde having the formulae:n where R 5 is hydrogen, lower alkyl, aryl, hydroxy, lower alkoxy, lower acyloxy, amino or lower alkylamino; each of Y and Z, independently of the other, is oxygen, sulfur or NR 6 ; and each of R 6 and R 7 , independently of the other, is hydrogen lower alkyl or R 6 and R 7 are joined to form a ring of 5-8 members; or (c) -(CH 2 ) n -OR 8 where n is 0, 1, 2, 3 or 4 and R 8 is hydrogen, lower acyl, lower alkylaminoacyl, lower alkylcarboxy, lower alkylcarboxamido, lower alkylcarboxamidoacyl or (lower acyloxy)-(lower alkyl); nand compounds that are pharmaceutically acceptable salts of such dibenzothiepins. They are useful in the treatment and control of allergic conditions such as allergic asthma and of other prostaglandin-related and TXA 2 -related diseases and are made into pharmaceutical compositions suitable for treating such conditions. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104744430-A |
| priorityDate | 1983-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 452.