http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0135351-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5610690048edbc271e03b26b23f76ff9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C239-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 |
| filingDate | 1984-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6b28dbc18a114739333172a9ac9b994 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3efaac12262c1b95a3f0b1459d4b6211 |
| publicationDate | 1985-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0135351-A1 |
| titleOfInvention | Manufacturing process for N-carbobenzyloxy-L-glutamic acid-alpha-cholinester salt |
| abstract | The invention relates to manufacturing process for a halide or an organic sulfonate of N-carbobenzyl-L-glutamic acid-a-cholinester in high purification, which is useful as e.g. hypotensive drug. According to the prior art, undesired γ-form byproduct is inevitably formed to be mingled with said a-form objective compound of which separation is difficult. It has been found that when using N-carbobenzyloxy-γ-tert. butyl-L-glutamic acid-dicyclohexyl-ammonium salt readily available in high purification as starting material, reacting N, N-dimethyl-aminoethylchloride therewith to form N-carbobenzyloxy-γ-tert. butyl-L-glutamic acid-a-dimethylaminoethyl ester which is quarternerized to form N-carbobenzyloxy-γ-tert. butyl-L-glutamic acid- α-cholinester salt, which is subjected to mild salt treatment, the objective compound can be obtained in high purification. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-567014-B1 |
| priorityDate | 1983-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 93.