| abstract |
A protein which is characterized by the following properties:(i) having a molecular weight of from about 5,000 to about 160,000 when the value is obtained from a calibration curve showing a relationship between the molecular weight and the amount eluted obtained by means of high-performance liquid chromatography using as marker proteins; thioglobin (with a molecular weight (M.W.) of 670,000), bovine y-globulin (with a M.W. of 158,000) fowl ovoalbumin (with a M.W. of 44,000), equine myoglobin (with a M.W. of 17,000), and vitamin B<sub>12</sub> (with a M.W. of 1,350);(ii) composed predominantly of neutral and acidic amino acids and containing significant amounts of glutamic acid and aspartic acid as the acidic amino acids;(iii) having a cell growth stimulating activity; and(iv) being substantially free of nucleoside phosphotransferase, which is useful as a wound treatment agent and a promoting agent in the synthesis of DNA, and so forth. |