| abstract |
Compounds of the formula (I):n and their salts are histamine H 2 -antagonists, wherein: R° is 2- guanidinothiazol-4-yl or a group R 1 R 2 N(CH 2 ) n Z- wherein R 1 and R 2 are hydrogen or various substituted alkyl groups or are joined together to form a ring; n ist 1 to 6; Z is 2,5-furanyl, 2,5-thienyl, 2,4-pyridyl (wherein R 1 R 2 N(CH 2 )n- is at position 4), 2,4-thiazolyl (wherein R 1 R 2 N(CH 2 ) n - is at position 2) or 1,3- or 1,4-phenylene; m is zero or one; Y is a bond, oxygen, sulphur or methylene; p is 2 to 4; q is zero or one; R 3 is hydrogen or C 1-6 alkyl; and R 4 is hydrogen or C 1-6 alkanoyl. n Pharmaceutical compositions containing them are described as are processes for their preparation and intermediates therefor. |