| abstract |
The present invention relates, in particular, to the chemical compounds of formula 1: in which R, is a radical corresponding to an amino acid R, -COOH, [A] is a C 2 or C 3 alkylene radical which may be substituted by a C 1 to C 3 alkyl radical, a hydroxy, hydroxycarbonyl or a radical -COR where R is an amino radical or -NH-CH 2 -CO 2 -H, R 2 is a protective radical of the thiol function which releases the thiol function in vivo, R. is hydrogen or linked to the group R 2 forms a protective cycle of R. thiol function;n n n as well as the salts of these compounds with pharmaceutically acceptable acids.n n n The invention also relates to the application of these compounds as radioprotective agents and to a process for their preparation. |