| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-88 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-403
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-056
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-443
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-08 |
| filingDate |
1984-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1987-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
1987-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0127099-B1 |
| titleOfInvention |
Process for the preparation of optically active carbazole derivatives, r- and s-carbazole derivatives, and pharmaceutical compositions containing these compounds |
| abstract |
A process for the preparation of S- or R-carbazole derivatives of the general formula: <IMAGE> in which R is an unsubstituted or substituted amino radical and pharmacologically acceptable salts, by either reacting R-(-)-epichlorohydrin (for the S-carbazole derivative); or reacting an S-epoxide derivative of the general formula: <IMAGE> in which R1 is the residue of a substituted sulphonic acid derivative (for the R-carbazole derivative); with 4-hydroxycarbazole and then with ammonia or a substituted amine of the general formula RH, and recovering the compound or converting it to a pharmacologically acceptable salt. The new R-(+)- and S-(-)-carbozole derivatives provided by the inventive process have unexpected beta blocking and vasodilatory properties and are useful in pharmaceutical compositions. R-(+)-carbazole derivatives are also useful for the treatment of glaucoma. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7056942-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7126008-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7605274-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0918055-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7485663-B2 |
| priorityDate |
1983-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |