| abstract |
There are described compounds of formula I, n nin which R₁ represents benzofurazanyl, pyridyl or phenyl, nthe pyridyl or phenyl being substituted, n-COOR₂ and -COOR₃ are various ester groups, nY and Z together form a bond, and additionally, when R₈ is nan electron withdrawing group Y may be hydrogen and Z may nbe hydroxy, none of R₇ and R₈ represents alkyl Cl to 6 and the other nrepresents -CONR₁₀R₁₁; -CSNH₂; -C(=NH)SR₉; -S(O) m R₉; nphenyl optionally substituted by one or more of alkyl Cl to 6, nhalogen, alkoxy Cl to 6 or nitro; alkyl Cl to 6 substituted by nhalogen; or furanyl, nor R₇ and R₈ may be the same or different and each nrepresents phenyl optionally substituted by one or more of nalkyl Cl to 6, halogen, alkoxy Cl to 6 or nitro; amino; alkyl Cl to n6 substituted by halogen; -CN; -CH₂OH; -CHO or -CH(OR₉)₂, nm is 0 or 1 nR₉ is alkyl Cl to 6, and nR₁₀ and R₁₁ each independently represent hydrogen or nalkyl Cl to 6, or together with the nitrogen atom to which they nare attached form a 5 or 6 membered heterocyclic ring. n There are also described processes for making the comnpounds, and pharmaceutical, eg calcium antagonist, formulantions containing them. |