| abstract |
A diaz(ep)ine bis(N-amidinoamidine) derivative of the formula:-n or a tautomeric form thereof, wherein R 10 , R", R 12 . R 13 , R", R 15 , R 16 and R 17 , which may be the same or different, are each hydrogen, a 1-16C alkyl radical, a 3-18C cycloalkyl or cycloalkylalkyl radical, or an optionally-substituted phenyl (1-4C alkyl) radical, or R'°, R" and the nitrogen atom to which they are attached, or R 12 and R" and the nitrogen atom to which they are attached, or R 14 and R 15 and the nitrogen atom to which they are attached, or R 16 and R 17 and the nitrogen atom to which they are attached, which may be the same or different, are each a 1-azetidinyl, 1-pyrrolidinyl, piperidino, hexamethyleneimino, heptamethyleneimino, morpholino or 4-(1-8C alkanoyl)-1-piperazinyl radical, or R 10 and R 14 together with the two nitrogen atoms to which they are attached and the intervening carbon atom, or R 12 and R 16 together with the two nitrogen atoms to which they are attached and the intervening carbon atom, each forms a 1,3-diazaheterocyclic radical of 5 to 7 atoms, which heterocyclic radicals may be the same or different; and m is 2 or 3; provided that R'°, R", R 12 , R 13 , R 14 , R' 5 , R" and R 17 togethercontain 16to 28 carbon atoms, and the acid addition salts thereof, processes for their manufacture and antibacterial and antifungal compositions and methods using said compounds. |