| abstract |
Compounds of the following formula are disclosed:n R - O - CO - X - CO - Zn wherein R is a dimeric indole-dihydroindole radical derived from a 4-acetoxy or 4-hydroxy antineoplastic dimer indoledihydroindole alkaloid, wherein Z is OR wherein R is the same or different, OH, OC1-3alkyl, NH2, NHNH2, an acylating group (Z<1>) or a carboxy protecting group (Z<2>), and wherein X is C1-4 straight chain alkylene, C2-8branched alkylene, C2-4alkenylene, C3-4alkynylene, C3-6cycloalkylene, phenylene, C1-4hydroxy substituted C1-4alkylene or a direct bond; and acid addition salts thereof. The compounds in which Z is OR, OH, OC1-3alkyl, NH2 or NHNH2 have utility as antitumor compounds and the remaining compounds are useful as intermediates in further synthesis. |