| abstract |
17-haloethynyl steroids of the partial formula <IMAGE> wherein R1 is hydrogen or methyl, R2 is alkyl of 1-4 carbon atoms, acyl of 1-7 carbon atoms, trimethylsilyl, 2-tetrahydropyranyl, or nitrate, X is bromine or iodine, and V is methylene, ethylene, vinylene, ethylidene, vinylidene or cyclopropylene, can be prepared by treating an ethynyl steroid of the partial formula <IMAGE> wherein R1, R2, and V are as defined above, in an inert solvent with a brominating agent or an iodinating agent in the presence of a silver salt. Certain new compounds are also provided. |